Tablet Dissolution Testing

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We provide the widest range of automation for Tablet Dissolution testing.

Closed Loop Dissolution Testing

This option uses our IDIS software to control dissolution testers and spectrophotometers on standalone or networked workstation.

Dissolution tester drivers are available for Agilent, Distek, Hanson, Sotax, Erweka, Logan, Pharmatest;  and spectrophotometer drivers for Agilent, Thermo, PGI, Perkin Elmer and Shimadzu.

Sample is pumped before the time interval and a reading is acquired from the spectrophotometer at Intervals configured by the user. The dissolution result is calculated and displayed on a local workstation or on a networked WAN workstation where it can be accessed anywhere in the world in real time.

Professional Informative and colourful reports are easily configured by dragging and dropping report objects (graph, data table etc.,) to create templates.

Collection, Sample Preparation and UV Measurement Dissolution Testing

This dissolution testing option can be used for analysis that cannot be measured online, for example where sample concentration is high even when using small pathlength Flow Cells or when samples need to be prepared prior to analysis for UV or HPLC.

Sample are collected into Test Tubes which can be analytically diluted with dilution ratios as high as 1:30, or serially diluted to much higher dilution ratios.

After mixing, samples are injected into the spectrophotometer, Absorbance data is read and dissolution profile calculated in real time.

 

Collection, Sample Preparation and HPLC Measurement Dissolution Testing

We provide unique fully automated HPLC analysis when connected to Agilent ChemStation with 1100 and 1200 series HPLC’s or semi-automatically with other makes of HPLC.

Samples are collected into HPLC vials which can be further analytically diluted with dilution ratios as high as 1:30, or serially diluted to much higher dilution ratios.

After mixing, samples are injected into the HPLC.
With ChemStation, chromatography results are acquired, and the dissolution profile is calculated in real time.

The laborious task of creating Sample Set / Sequence Tables are manged by our IDIS software.
After creation, the Sample Set / Sequence Table are seamlessly transferred automatically to the HPLC CDS. IDIS also acquires peak results from the HPLC and plots the dissolution in real time.

 

Media Addition with pH Measurement Dissolution Testing

All dissolution configurations can have the option for Media Addition with or without pH measurement.

We can  measure the pH in  just 1 vessel or in all vessels and the pH values are numerically and graphically displayed in real time. Additionally, very specialised algorithms allows pH Titration to a set pH value. The Media Addition and pH Measurement option can be used with Closed Loop UV and with ASP2000 systems for UV or HPLC analysis

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